Dose-Dependent Effect of Cobra Venom on Testes in Mice

Effect of Cobra Venom Factor Treatment

Squirrel monkeys were significantly depleted of complement by a nontoxic protein constituent of cobra venom, and the influence of cobra factor (CoF) treatment on the course of Escherichia coli bacteremia was studied. Striking neutropenia occurred rapidly in control animals while the rate of occurrence of neutropenia was 20 to 30 times slower in the CoF-treated animals, suggesting that the E. co...

Cobra Venom Factor and Ketoprofen Abolish the Antitumor Effect of Nerve Growth Factor from Cobra Venom

We showed recently that nerve growth factor (NGF) from cobra venom inhibited the growth of Ehrlich ascites carcinoma (EAC) inoculated subcutaneously in mice. Here, we studied the influence of anti-complementary cobra venom factor (CVF) and the non-steroidal anti-inflammatory drug ketoprofen on the antitumor NGF effect, as well as on NGF-induced changes in EAC histological patterns, the activity...

The Effect of Cobra Venom on Frog Intestine

The Effect of Cobra Venom Factor on Hemostasis

Recent investigations have indicated an association between the coagulation and complement systems. Our present studies, designed to explore this association further, demonstrated that a purified anticomplementary fraction of cobra venom, cobra venom factor (CVF), produced significant changes in hemostasis when injected into guinea pigs. Some of the effects described may be secondary to the tra...

Cobra Venom in Therapeutics

During the past eight years the senior author has been engaged in testing the pharmacological action and therapeutic properties of Indian snake venoms. Chopra and Chowhan (1932 and 1935) showed that the efficacy of the cobra and other snake venoms in relieving the pain of malignant growths and of neuritis and neuralgias was probably due to the presence of such active principles as neurotoxin. The